Goal

Longevity

Compounds18

With human trials4

Nothing here has been tested against the endpoint it claims. Read it with that in mind.

Longevity is the hardest goal on this site to evaluate honestly, because the endpoint takes decades and nothing on the list has ever been measured against it. What is actually being targeted is a set of proxies: mitochondrial function, NAD+ availability, inflammatory tone, telomere biology, growth hormone and IGF-1 signaling. Every claim here is therefore a claim about a marker, not about lifespan.

No compound reaches 5/5. The four at 4 are epitalon, MOTS-c, NAD+ and SS-31, and each carries a specific caveat. Epitalon’s human evidence comes almost entirely from a single Russian research group and has not been independently replicated. MOTS-c is preclinical, with human data that is observational rather than interventional. Injected NAD+ is weakly supported — most controlled trials study oral precursors such as nicotinamide riboside rather than parenteral NAD+. SS-31 has the strongest trial record of the four and mixed results from it. Below them, GHK-Cu and sermorelin at 3 and a long tail of growth hormone secretagogues at 2, where a real tension sits unresolved: chronically raising IGF-1 is close to the opposite of what most longevity biology would suggest.

Hold this page to a higher standard than any other on the site. Prefer the compounds whose dosing convention is a short pulsed course over those run continuously, decide in advance what marker you would measure, and treat any anti-ageing claim that arrives with a mechanism story and no trial as exactly that. The interventions with the strongest longevity evidence — sleep, muscle mass, cardiorespiratory fitness, not smoking — are unglamorous and are not sold in vials.

How to read this

Match — how squarely it aims here

The weight the dataset gives this compound for this goal, 1 to 5. It describes intent and mechanism, not benefit, and not direction: a 5 means the compound acts hard on the system in question.

5/5primary use

Evidence — whether anyone has shown it

Read from the compound’s evidence note and handling grade, for the compound as a whole rather than for this goal alone. A 5/5 match on animal data is a hypothesis, not a result.

Human trialsRandomized or controlled human trials exist, or the compound holds a regulatory approval somewhere. Trials existing is not the same as trials succeeding — some of these were negative.
Some human dataPublished human work exists but is small, early-phase, acute, or from a single group that nobody has replicated.
Animal data onlyThe case rests on rodent and cell work. Doses shown are extrapolated, not established in people.
Anecdotal onlyNo published trial record of any kind. Every number comes from vendor packaging and community practice.

18 compounds, strongest match first

Ranked for longevity

Match 4/5 · Strong secondary

Match 3/5 · Meaningful contributor

Match 2/5 · Marginal

Match 1/5 · Incidental

Named stacks

Protocols built around this goal

Energy / Immunity (NAD+ + Glutathione + Methyl-B12)Primary goal8 weeksBeginnerThe three things that end up in almost every "energy and immunity" product: NAD+ for mitochondrial redox, glutathione as the headline antioxidant, and methylcobalamin because B12 is what people associate with energy. They are combined because they are convenient to sell together, not because anyone has shown the three work better in combination than separately.Advanced Mitochondrial (MOTS-c + SS-31)Primary goal8 weeksAdvancedThe two most talked-about mitochondrial peptides run together: MOTS-c, a mitochondrially encoded peptide that activates AMPK, and SS-31 (elamipretide), a tetrapeptide that binds cardiolipin on the inner mitochondrial membrane. Two different points of attack on the same organelle, which is the whole rationale. Graded advanced because both are thin on human data and because nothing you can measure will tell you whether it worked.GH Pulse (Ipamorelin + CJC-1295 no-DAC)Also targets12 weeksBeginnerThe standard growth hormone secretagogue pairing: a GHRH analogue (CJC-1295 without DAC, also sold as Mod GRF 1-29) plus a ghrelin receptor agonist (ipamorelin), injected together so the two mechanisms produce a larger pulse than either alone. Both are short-acting, which is the point - it mimics a natural pulse instead of flattening it.Tirzepatide + TesamorelinAlso targets26 weeksAdvancedThe same idea as Retatrutide + GH Pulse, built from the two compounds in their classes that actually have FDA labels: weekly tirzepatide for the weight loss, daily tesamorelin for visceral fat and the GH axis. It is the conservative version of the muscle-sparing stack - better documented on both sides, more expensive, and with a clearer glucose problem to watch.Sleep Nasal (DSIP + Epitalon)Also targets2 weeksIntermediateDSIP and epitalon run together on a short evening course, sold as a sleep stack and increasingly as a nasal spray. Both names promise more than the data delivers: DSIP is named after how it was discovered, not after a demonstrated hypnotic effect, and epitalon's sleep and longevity claims come almost entirely from one unreplicated Russian group. This entry exists to describe the stack accurately, not to recommend it.

Not sure this is your goal

Most people arrive wanting two or three of these at once, and the honest answer is usually to pick one and run it properly. The quiz weighs your goals against your experience, the routes you will tolerate and your contraindications, then shows its reasoning rather than just a name.

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Other goals

Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.