MyPeptideHelper

GH secretagogue

MK-677 (Ibutamoren)

Controlled trials

Orally active, long-acting ghrelin receptor (GHS-R1a) agonist that raises GH and IGF-1 for around 24 hours per dose.

OralIntermediateNot approved anywhereappetite controlrecovery and sleepmuscle growthinjury repair

Also known as Ibutamoren · Ibutamoren mesylate · MK-0677 · L-163,191

At a glance

Dose summary

Typical dose15 mg
Range10 mg–25 mg
FrequencyDaily
Half-life~24 h
ScheduleOnce daily
Cycle length16 weeks
RouteOral
Experience levelIntermediate
Evidence gradeControlled trials
ApprovalNot approved anywhere
Where the dose comes fromPublished trial dosing

Form

Nothing to reconstitute

MK-677 (Ibutamoren) is taken by mouth, not injected, so there is no vial, no diluent and no draw volume. The typical dose is 15 mg per administration — that is the number on the capsule or tablet, and the reconstitution calculator deliberately excludes this compound.

Mechanism & evidence

What it is, and what is known

Orally active, long-acting ghrelin receptor (GHS-R1a) agonist that raises GH and IGF-1 for around 24 hours per dose. It has been through multiple human trials, including a two-year study in older adults, but was never approved for any indication and trials also flagged increased fasting glucose and reduced insulin sensitivity. It is a non-peptide small molecule, so it is taken by mouth rather than injected.

The caveat

Multiple human trials including a two-year study — which also flagged raised fasting glucose and reduced insulin sensitivity. Never approved for any indication.

Tolerability

Reported side effects

  • Pronounced increase in appetite, often within the first few days
  • Water retention, puffiness in the face and ankles, and rapid scale weight gain
  • Raised fasting blood glucose and reduced insulin sensitivity — a real concern for anyone prediabetic or diabetic, and worth monitoring with bloodwork on longer runs
  • Lethargy or grogginess the morning after a pre-bed dose
  • Numbness or tingling in the hands, sometimes carpal-tunnel-like
  • Vivid dreams and deeper but occasionally disrupted sleep
  • Mild joint aches at higher doses

Hard stops

Do not use this if

  • Pregnancy, possible pregnancy, or breastfeeding
  • Active, suspected or recently treated malignancy
  • Under 18

These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.

Handling

Storage

Sealed, as supplied24 months
Once opened30 days

Keep it cold, dry and dark. The figures above are shelf-life conventions, not stability testing on the product you bought.

Combinations

Commonly stacked with

CJC-1295 without DAC (Mod GRF 1-29)Limited human dataGH secretagogueBPC-157Limited human dataHealing & repair

Stacking multiplies the side-effect surface and makes it impossible to tell which compound did what. Add one thing at a time.

References

Sources

Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.