Immune
Thymosin Alpha-1
A 28-amino-acid thymic peptide with genuine clinical use.
Also known as Tα1 · Ta1 · Thymalfasin · Zadaxin
At a glance
Dose summary
Reconstitution
What to draw, at the usual vial
A 10 mg vial reconstituted with 2 mL of bacteriostatic water gives 5.00 mg/mL. A typical 1.6 mg dose is 0.320 mL — pull the plunger to 32 units on a U-100 syringe.
Same dose, other vial sizes
| Vial | Water | Concentration | Draw | Units | Doses |
|---|---|---|---|---|---|
| 1.60 mg | 2 mL | 0.80 mg/mL | 2.000 mL | 200 units | 1 |
| 5 mg | 2 mL | 2.50 mg/mL | 0.640 mL | 64 units | 3 |
| 10 mg | 2 mL | 5.00 mg/mL | 0.320 mL | 32 units | 6 |
The highlighted row is the one quoted above: the smallest listed vial that holds at least four typical doses. Change any of it — a different vial, more or less water, a different dose — on the reconstitution calculator, which draws the syringe to true U-100 graduations.
Mechanism & evidence
What it is, and what is known
A 28-amino-acid thymic peptide with genuine clinical use. Marketed as thymalfasin (Zadaxin) and approved in a number of countries outside the US for chronic hepatitis B and C and as a vaccine adjuvant; it is NOT FDA approved. The best-established regimen is the labeled one: 1.6 mg subcutaneously twice weekly, which is where the typical dose here comes from. Higher daily dosing has been studied in sepsis and in hospitalised COVID-19 patients, which is the basis for the upper end of the range; that is an acute inpatient context, not a wellness protocol.
Approved hepatitis courses run 24 weeks or longer, so the 8-week cycle shown here reflects common non-clinical use rather than the label. Reported plasma half-life is roughly 2 hours, but its immunological effect outlasts plasma levels.
The caveat
Marketed as thymalfasin and approved in several countries outside the US, but not FDA approved. The labeled hepatitis courses run far longer than the cycle shown here.Tolerability
Reported side effects
- Injection site discomfort, redness or transient swelling
- Short-lived flu-like feeling or fatigue after a dose
- Muscle aches
- Rare rash
Hard stops
Do not use this if
- Pregnancy, possible pregnancy, or breastfeeding
- Under 18
These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.
Handling
Storage
Keep it cold, keep it dark, and label the vial with the date you mixed it. Discard anything cloudy or past the window above.
Combinations
Commonly stacked with
Stacking multiplies the side-effect surface and makes it impossible to tell which compound did what. Add one thing at a time.
References
Sources
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.