Run for longevity
Energy / Immunity (NAD+ + Glutathione + Methyl-B12)
beginner8 weeksThe three things that end up in almost every "energy and immunity" product: NAD+ for mitochondrial redox, glutathione as the headline antioxidant, and methylcobalamin because B12 is what people associate with energy. They are combined because they are convenient to sell together, not because anyone has shown the three work better in combination than separately.
Also sold as Energy strip, Immunity strip, NAD+ / glutathione / B12, Cellular energy stack.
Cautions — 10 on record
Read before running any of this
- B12 only does something if you are short of it. Injecting B12 into someone with a normal level does not produce energy - the entire "B12 for energy" association comes from correcting deficiency. Get a serum B12 before you start, and ideally methylmalonic acid or homocysteine, which pick up functional deficiency that a normal serum B12 can hide. If you are replete, this component is doing nothing for you.
- Taking B12 blindly can also do harm by omission: supplementing it corrects the anemia of B12 deficiency while the neurological damage continues, so it can mask the thing that would otherwise have sent you to a doctor. That is an argument for testing first, not for skipping it.
- The three are combined because they are packaged together. There is no published work on this trio, no interaction anyone has demonstrated, and no reason to think their effects compound. Treat it as three separate decisions that happen to share a bottle.
- Route changes everything here, and a strip, spray or capsule is not the doses above. Every figure on this page is parenteral convention. Oral and sublingual glutathione is largely broken down by gamma-glutamyltransferase before absorption; oral NAD+ itself is not established at all, and the trials people cite for it actually studied the precursors nicotinamide riboside and NMN, not NAD+. Do not read a mcg figure here across onto a dissolving film.
- Human evidence for injected NAD+ specifically is weak. Most of the controlled work in this area is on oral precursors, and the anti-ageing claims attached to injected NAD+ run well ahead of the data.
- Subcutaneous NAD+ is notoriously painful, and pushing it too fast produces flushing, chest tightness, nausea, cramping and a wave of anxiety. That reaction is a rate problem - slow the injection down rather than abandoning the dose or, worse, deciding it means the product is working.
- Glutathione carries specific route risks that the injectable form does not: nebulized or inhaled glutathione can trigger bronchospasm, particularly in asthmatics and people with sulphite sensitivity. Sustained high-dose use also lightens skin, which is the intended effect for some users and an unwanted one for others, and several national regulators have issued safety warnings about high-dose IV glutathione used cosmetically.
- The immunity half of the name is the weakest part. Glutathione's role in immune function is real biochemistry, but no trial shows that supplementing it - by any route - reduces infections in healthy adults.
- If persistent fatigue is the actual complaint, the differential matters far more than this stack: thyroid disease, iron deficiency, sleep apnoea, depression and anemia are all common, all testable and all treatable. Spending eight weeks on injections before running those tests is the main way this stack causes harm.
- Not for use in pregnancy, and not for under-18s.
Components
What is in it, and when
| Compound | Dose | Frequency | Time | Notes | |
|---|---|---|---|---|---|
| NAD+ | 100 mg25 mg–250 mg | Three times a week3×/week | Morning | 100 mg. Three times weekly rather than daily is the usual pattern subcutaneously, because the injection stings badly enough that most people cannot keep a daily schedule. Start at the bottom of the range and inject slowly. IV NAD+ at 250-1000 mg per infusion is a different thing entirely and the doses do not transfer. | Calculator → |
| Glutathione | 600 mg100 mg–2000 mg | Three times a week3×/week | Morning | 600 mg, a typical single parenteral dose. Clinic practice is one to three times a week rather than daily. Oral and sublingual products are taken daily instead, but at a much lower effective exposure - swallowed glutathione is largely hydrolysed back to its amino acids before it reaches the circulation, so an oral 600 mg is not a parenteral 600 mg. | Calculator → |
| Methylcobalamin (Methyl-B12) | 1 mg500 mcg–5 mg | Once a week1×/week | Morning | 1000 mcg weekly is the standard replacement dose and the only component here with a well-established clinical convention behind it. Note the scale difference: this is one thousandth of the glutathione dose in the same stack, so the same syringe markings mean completely different things for the three vials. Label them. | Calculator → |
Doses are per administration, in the canonical unit. The second line under each dose is the range people run. Each calculator link prefills the reconstitution math for that component.
Delivered dose vs standalone dose
How these doses compare to running each compound alone
Each bar is that compound’s own dose range from its monograph, with a marker where this protocol puts it. A marker outside the band means the protocol is not dosing that compound the way it is dosed on its own — for a fixed-ratio vial that is arithmetic, not a choice.
NAD+
Within standalone range- Per dose
- 100% of typical
- Per week
- 300 mg · 100% of standalone
- Cycle total
- 2400 mg · 24 doses
100 mg. Three times weekly rather than daily is the usual pattern subcutaneously, because the injection stings badly enough that most people cannot keep a daily schedule. Start at the bottom of the range and inject slowly. IV NAD+ at 250-1000 mg per infusion is a different thing entirely and the doses do not transfer.
Glutathione
Within standalone range- Per dose
- 100% of typical
- Per week
- 1800 mg · 43% of standalone
- Cycle total
- 14400 mg · 24 doses
Dosed three times a week here against once daily standalone, so the weekly figure is the fairer of the two comparisons.
600 mg, a typical single parenteral dose. Clinic practice is one to three times a week rather than daily. Oral and sublingual products are taken daily instead, but at a much lower effective exposure - swallowed glutathione is largely hydrolysed back to its amino acids before it reaches the circulation, so an oral 600 mg is not a parenteral 600 mg.
Methylcobalamin (Methyl-B12)
Within standalone range- Per dose
- 100% of typical
- Per week
- 1 mg · 100% of standalone
- Cycle total
- 8 mg · 8 doses
1000 mcg weekly is the standard replacement dose and the only component here with a well-established clinical convention behind it. Note the scale difference: this is one thousandth of the glutathione dose in the same stack, so the same syringe markings mean completely different things for the three vials. Label them.
Schedule — 8 weeks
Week by week
| Compound | 1Week 1 | 2Week 2 | 3Week 3 | 4Week 4 | 5Week 5 | 6Week 6 | 7Week 7 | 8Week 8 | Cycle total |
|---|---|---|---|---|---|---|---|---|---|
| NAD+100 mg · 3×/wk | 2400 mg24 doses | ||||||||
| Glutathione600 mg · 3×/wk | 14400 mg24 doses | ||||||||
| Methylcobalamin (Methyl-B12)1 mg · 1×/wk | 8 mg8 doses |
This protocol outlasts some of its own components
- NAD+ is typically cycled for 4 weeks; this protocol runs 8 weeks, so weeks 5–8 are past that. In a fixed-ratio vial you cannot drop it early without dropping everything else with it.
The dataset records one dose per component, so every dosing week is identical. Where a protocol note describes a loading phase followed by maintenance, that phase change is in the note, not in the schedule — read the component notes before assuming the grid is the whole story.
Evidence
What is actually known
This is packaged as a product rather than derived from a studied protocol. Nothing has been published on NAD+ with glutathione with methylcobalamin. Each is assessed on its own below, and none of the three has been shown to raise energy or immunity in a healthy, replete adult. METHYLCOBALAMIN is the only one with solid ground under it, and only for one purpose: correcting B12 deficiency, where the effect is large, well documented and completely absent if you were not deficient in the first place. GLUTATHIONE is a genuine tripeptide and the body's principal intracellular antioxidant, and there is real controlled human work on it - intravenous use in Parkinson's disease and in platinum-neuropathy supportive care, nebulized use in cystic fibrosis, and an early-phase intranasal formulation. Note what that list does not include: general fatigue or immunity in healthy people, and the oral and subcutaneous routes most consumer products use. NAD+ has the weakest position of the three despite being the headline ingredient. The controlled trials people cite are on oral precursors; injected and infused NAD+ itself has little more than small pilot pharmacokinetic work behind it. NOT REPEATED FROM THE VENDOR GUIDE: the NAD+ timeline claiming improved focus and an energy lift within the first few sessions, reduced fatigue by two weeks and "enhanced mitochondrial resilience and clearer thinking" by six. Those are marketing, and they are exactly the claims a stack like this cannot support.
SourcesPubMedClinicalTrials.gov
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.