GH secretagogue
Ipamorelin
Selective ghrelin receptor (GHS-R1a) agonist that triggers a growth hormone pulse with little effect on cortisol or prolactin, which is the main reason it is chosen over hexarelin or GHRP-6.
Also known as NNC 26-0161
At a glance
Dose summary
No regulator and no trial set these numbers. They describe what people actually do, recorded so you can see the range rather than guess at it — which is not the same thing as a recommendation.
Reconstitution
What to draw, at the usual vial
A 5 mg vial reconstituted with 2 mL of bacteriostatic water gives 2.50 mg/mL. A typical 200 mcg dose is 0.080 mL — pull the plunger to 8 units on a U-100 syringe.
Same dose, other vial sizes
| Vial | Water | Concentration | Draw | Units | Doses |
|---|---|---|---|---|---|
| 5 mg | 2 mL | 2.50 mg/mL | 0.080 mL | 8 units | 25 |
| 10 mg | 2 mL | 5.00 mg/mL | 0.040 mL | 4 units | 50 |
The highlighted row is the one quoted above: the smallest listed vial that holds at least four typical doses. Change any of it — a different vial, more or less water, a different dose — on the reconstitution calculator, which draws the syringe to true U-100 graduations.
Mechanism & evidence
What it is, and what is known
Selective ghrelin receptor (GHS-R1a) agonist that triggers a growth hormone pulse with little effect on cortisol or prolactin, which is the main reason it is chosen over hexarelin or GHRP-6. Published human work is limited to small early-phase and post-operative ileus studies; development was discontinued and it is NOT an approved medicine anywhere. Everything sold to consumers is research-chemical grade, so the community 100-300 mcg per dose range comes from practice rather than from a label.
The caveat
Small early-phase and post-operative ileus studies; development was discontinued.Tolerability
Reported side effects
- Injection site redness or itching
- Head rush or flushing shortly after injection
- Water retention and morning puffiness
- Tingling or numbness in the hands, which can reflect carpal tunnel pressure
- Vivid dreams or grogginess when dosed pre-bed
Hard stops
Do not use this if
- Pregnancy, possible pregnancy, or breastfeeding
- Active, suspected or recently treated malignancy
- Under 18
These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.
Handling
Storage
Keep it cold, keep it dark, and label the vial with the date you mixed it. Discard anything cloudy or past the window above.
Combinations
Commonly stacked with
Stacking multiplies the side-effect surface and makes it impossible to tell which compound did what. Add one thing at a time.
Where it shows up
Protocols using this compound
References
Sources
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.