GH secretagogue
Hexarelin
Synthetic hexapeptide ghrelin receptor (GHS-R1a) agonist and one of the most potent GH secretagogues studied in humans, with additional cardiac data.
Also known as Examorelin · Hexarelin acetate
At a glance
Dose summary
No regulator and no trial set these numbers. They describe what people actually do, recorded so you can see the range rather than guess at it — which is not the same thing as a recommendation.
Reconstitution
What to draw, at the usual vial
A 2 mg vial reconstituted with 2 mL of bacteriostatic water gives 1.00 mg/mL. A typical 100 mcg dose is 0.100 mL — pull the plunger to 10 units on a U-100 syringe.
Same dose, other vial sizes
| Vial | Water | Concentration | Draw | Units | Doses |
|---|---|---|---|---|---|
| 2 mg | 2 mL | 1.00 mg/mL | 0.100 mL | 10 units | 20 |
| 5 mg | 2 mL | 2.50 mg/mL | 0.040 mL | 4 units | 50 |
The highlighted row is the one quoted above: the smallest listed vial that holds at least four typical doses. Change any of it — a different vial, more or less water, a different dose — on the reconstitution calculator, which draws the syringe to true U-100 graduations.
Mechanism & evidence
What it is, and what is known
Synthetic hexapeptide ghrelin receptor (GHS-R1a) agonist and one of the most potent GH secretagogues studied in humans, with additional cardiac data. Its defining practical problem is tachyphylaxis: repeated dosing blunts the GH response over roughly two to four weeks, which is why it is cycled short rather than run continuously. It also lacks the selectivity of ipamorelin, so prolactin and cortisol elevation are expected at higher doses.
The caveat
Well studied as a GH secretagogue, but tachyphylaxis blunts it within weeks.Tolerability
Reported side effects
- Marked receptor desensitisation — the GH response falls off within a few weeks of continuous daily use, so cycles are kept short with washout periods
- Raises prolactin and cortisol more than ipamorelin does
- Strong hunger spike within 20 to 30 minutes of dosing
- Water retention, puffiness and numb or tingling hands
- Head rush, flushing or transient light-headedness after injection
- Injection site irritation
Hard stops
Do not use this if
- Pregnancy, possible pregnancy, or breastfeeding
- Active, suspected or recently treated malignancy
- Under 18
These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.
Handling
Storage
Keep it cold, keep it dark, and label the vial with the date you mixed it. Discard anything cloudy or past the window above.
Combinations
Commonly stacked with
Stacking multiplies the side-effect surface and makes it impossible to tell which compound did what. Add one thing at a time.
References
Sources
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.