Run for focus and cognition

Focus Nasal (Semax + Selank)

beginner4 weeks

Semax and selank in a single pre-mixed nasal spray, run as a short course: semax for focus and drive, selank as the anxiolytic counterweight that takes the edge off it. This is the same two compounds as the Semax + Selank entry in this library - the difference is the delivery format, not the pharmacology. It is here because the nasal route is the point: these two are formulated intranasally on purpose, and it is the one stack in this library that involves no needles at all.

Duration4 wk

Compounds2

Ratio-lockednone

Off standalone rangenone

Also sold as Focus spray, Semax + Selank nasal, NA-Semax + NA-Selank, Nootropic nasal stack.

Cautions — 9 on record

Read before running any of this

Nasal doses and injection doses are not interchangeable. Intranasal absorption of small peptides is variable and, for these two specifically, has not been characterized in any Western study; the figures above are what people put up their nose, not a bioavailability-corrected equivalent of an injected dose. Do not convert one route into the other, in either direction.
Nasal dosing is imprecise in ways injections are not. How much you absorb depends on the concentration your solution was made up at, spray technique, how much runs down the back of your throat, and whether you are congested. A cold changes your dose. Expect day-to-day variation and do not chase it with more sprays.
Neither compound is approved outside Russia and some CIS states. In the US, UK and EU both are unapproved research chemicals with no verified purity, and a pre-mixed "Focus" spray is a further step removed - you are trusting someone else's reconstitution and concentration as well as their raw material.
Run short courses of 2-4 weeks with a break. That is how they are used clinically in Russia; selank courses there are conventionally 10-14 days. Continuous use is not the studied pattern and there is no long-term data.
Selank interacts with GABAergic signaling. Be careful combining it with benzodiazepines, alcohol or other sedatives.
Semax can cause irritability, over-stimulation, headache and nasal irritation, particularly at the top of the range. Adding more selank to manage semax over-stimulation is treating a dosing error with a second compound.
If you have a psychiatric diagnosis or take an SSRI, SNRI or MAOI, do not add these without talking to your prescriber first.
A nasal spray is a personal item. Do not share the bottle, and replace the made-up solution on schedule - it goes into a mucous membrane, not through an alcohol-swabbed skin site.
Not for use in pregnancy, and not for under-18s.

Components

What is in it, and when

Compound	Dose	Frequency	Time	Notes
Semax	300 mcg100 mcg–1 mg	Twice daily14×/week	Morning	Per administration, not per day - Russian clinical convention is roughly 200-2000 mcg daily split across two or three sprays. Keep both doses before mid-afternoon; dosed late it interferes with sleep. The N-acetyl amidated form (NA-Semax) is more stable and is usually run at the lower end of this range. Split across both nostrils.	Calculator →
Selank	300 mcg150 mcg–900 mcg	Twice daily14×/week	Any time	Also per administration. Often staggered against semax - semax in the morning, selank later - or taken only on high-stress days rather than on a fixed schedule. If both go in the same session, leave 10-15 minutes between them so the second spray does not wash the first back out. Russian trial dosing runs considerably higher (roughly 1800-2700 mcg daily); the range here is the more conservative non-clinical practice.	Calculator →

Doses are per administration, in the canonical unit. The second line under each dose is the range people run. Each calculator link prefills the reconstitution math for that component.

Delivered dose vs standalone dose

How these doses compare to running each compound alone

Each bar is that compound’s own dose range from its monograph, with a marker where this protocol puts it. A marker outside the band means the protocol is not dosing that compound the way it is dosed on its own — for a fixed-ratio vial that is arithmetic, not a choice.

Semax

Within standalone range

Standalone 100 mcg–1 mg (typical 300 mcg)This protocol 300 mcg

Per dose: 100% of typical
Per week: 4.2 mg · 100% of standalone
Cycle total: 16.8 mg · 56 doses

Per administration, not per day - Russian clinical convention is roughly 200-2000 mcg daily split across two or three sprays. Keep both doses before mid-afternoon; dosed late it interferes with sleep. The N-acetyl amidated form (NA-Semax) is more stable and is usually run at the lower end of this range. Split across both nostrils.

Selank

Within standalone range

Standalone 150 mcg–900 mcg (typical 300 mcg)This protocol 300 mcg

Per dose: 100% of typical
Per week: 4.2 mg · 100% of standalone
Cycle total: 16.8 mg · 56 doses

Also per administration. Often staggered against semax - semax in the morning, selank later - or taken only on high-stress days rather than on a fixed schedule. If both go in the same session, leave 10-15 minutes between them so the second spray does not wash the first back out. Russian trial dosing runs considerably higher (roughly 1800-2700 mcg daily); the range here is the more conservative non-clinical practice.

Schedule — 4 weeks

Week by week

Dosing weeks for each component of Focus Nasal (Semax + Selank)
Compound	1Week 1	2Week 2	3Week 3	4Week 4	Cycle total
Semax300 mcg · 14×/wk					16.8 mg56 doses
Selank300 mcg · 14×/wk					16.8 mg56 doses

dosing past that compound’s own typical cycle length

This protocol outlasts some of its own components

Selank is typically cycled for 2 weeks; this protocol runs 4 weeks, so weeks 3–4 are past that. In a fixed-ratio vial you cannot drop it early without dropping everything else with it.

The dataset records one dose per component, so every dosing week is identical. Where a protocol note describes a loading phase followed by maintenance, that phase change is in the note, not in the schedule — read the component notes before assuming the grid is the whole story.

Evidence

What is actually known

ROUTE FIRST. Both are intranasal drugs by design. The Pro-Gly-Pro tails on both peptides exist to resist enzymatic breakdown, and the nose-to-brain path along the olfactory and trigeminal routes is the reason the Russian formulations are drops and sprays rather than ampoules. Vendor pages circulate confident intranasal bioavailability percentages for both; those numbers do not trace back to a published human study and are not repeated here. What can be said is that the nasal route is the studied one, not a compromise. EVIDENCE FOR THE COMPOUNDS. Both are registered medicines in Russia - semax for stroke and cognitive indications, selank for anxiety disorders, with small trials comparing it against benzodiazepines such as phenazepam. There is a real Russian-language clinical literature behind them. Western replication is essentially absent, most published work is small or in animals, and neither has been through FDA or EMA review. EVIDENCE FOR THE COMBINATION: none. There is no trial of semax with selank. The pairing logic - a stimulating peptide plus an anxiolytic one to smooth it out - is coherent and is what Russian practice and every vendor recommends, but it is a rationale, not a finding. They are sold together because they sell well together. If you have never run either, run semax alone first; it is the one doing the work you are probably buying this for, and half of people find they do not want the selank on top.

SourcesPubMed ClinicalTrials.gov

Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.