MyPeptideHelper

Healing & repair

Larazotide

Controlled trials

A zonulin antagonist taken orally as a capsule; it acts locally in the gut lumen and is essentially not absorbed systemically.

OralIntermediateNot approved anywheregut healthinflammationimmune support

Also known as Larazotide acetate · AT-1001 · INN-202

At a glance

Dose summary

Typical dose500 mcg
Range500 mcg–2 mg
Frequency3×/day
Half-lifeUnknown
ScheduleThree times daily
Cycle length12 weeks
RouteOral
Experience levelIntermediate
Evidence gradeControlled trials
ApprovalNot approved anywhere
Where the dose comes fromPublished trial dosing

No reliable human half-life has been published for Larazotide, so none is listed rather than guessed at.

Form

Nothing to reconstitute

Larazotide is taken by mouth, not injected, so there is no vial, no diluent and no draw volume. The typical dose is 500 mcg per administration — that is the number on the capsule or tablet, and the reconstitution calculator deliberately excludes this compound.

Mechanism & evidence

What it is, and what is known

A zonulin antagonist taken orally as a capsule; it acts locally in the gut lumen and is essentially not absorbed systemically. It has run randomized placebo-controlled trials in coeliac disease, including a phase 3 that was stopped for futility at interim analysis. Trial dosing was 0.5 mg three times daily before meals, with 1 mg and 2 mg arms performing no better than 0.5 mg. This app has no three-times-daily option, so the schedule below is an approximation of the studied regimen.

Not an approved medicine.

The caveat

The coeliac phase 3 was stopped for futility at interim analysis.

Tolerability

Reported side effects

  • Headache
  • Abdominal pain or bloating
  • Nausea
  • Upper respiratory tract infection reported in trials

Hard stops

Do not use this if

  • Pregnancy, possible pregnancy, or breastfeeding
  • Under 18

These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.

Handling

Storage

Sealed, as supplied24 months
Once opened30 days

Keep it cold, dry and dark. The figures above are shelf-life conventions, not stability testing on the product you bought.

Combinations

Commonly stacked with

BPC-157Limited human dataHealing & repairKPVAnimal data onlyHealing & repair

Stacking multiplies the side-effect surface and makes it impossible to tell which compound did what. Add one thing at a time.

References

Sources

Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.